Reproduction Abstracts

Introduction: Placentation involves trophoblast cell invasion into the decidua to remodel maternal arteries. Interleukin (IL)-11 is critical for human trophoblast cell migration/invasion in vitro, however its role in placentation in vivo has not been investigated. We hypothesised that IL11 plays a critical role in trophoblast function during placentation. The aim of this study was to examine the effect of IL11 inhibition on placentation in mice.<p class="...

Introduction: Ectopic pregnancy is unique to humans and a leading cause of maternal morbidity/mortality however the etiology remains unknown. Leukemia inhibitory factor (LIF) has roles in extravillous-trophoblast adhesion/invasion and is expressed in ectopic pregnancy. We hypothesised that LIF facilitates blastocyst adhesion/invasion in the fallopian tube (FT), contributing to ectopic pregnancy. LIF blockade could serve as a treatment strategy.Methods: W...